Traditional, unfairly forgotten, rarely used and promising drug delivery methods in ophthalmology: a clinical interpretation (part 1)

Author:

Kuroyedov A. V.1,Brzhesky V. V.2,Krinitsyna E. A.3

Affiliation:

1. P.V. Mandryka Military Clinical Hospital; N.I. Pirogov National Medical University

2. State Pediatric Medical University

3. N.I. Pirogov National Medical University

Abstract

Ocular targeted drug delivery is one of the most challenging tasks for pharmaceutical researchers and practical ophthalmologists. The possibilities of drug delivery to the eye are naturally determined by the anatomical structure of the eye and its physiological properties, which restrict the period when therapeutically required drug concentration could be maintained. Combined drug delivery schemes may, potentially, improve the patient’s acceptance of treatment, reduce side effects, increase efficacy, and eventually preserve vision.

Publisher

Real Time, Ltd.

Subject

Ophthalmology

Reference80 articles.

1. Krasnov M.L., Shul'pina N.B. Therapeutic ophthalmology. Moscow: Meditsina; 1985 (in Russian).

2. Krasnov M.M., Arnautova L.G. A new method of retrograde intraarterial administration of medicinal agents in a. ophthalmica in the treatment of eye diseases. Vestnik oftal’mologii. 1976; 6: 46–50 (in Russian).

3. Thassu D., Deleers M., Pathak Y., eds. Nanoparticulate Drug Delivery Systems. 1st Edition. New York: CRC Press; 2007.

4. Egorov E.A. Rational pharmacotherapy in ophthalmology. Moscow: Littera; 2004 (in Russian).

5. Bourlais C.L., Acar L., Zia H., et al. Ophthalmic drug delivery systems — recent advances. Prog. Retin. Eye. Res. 1998; 17 (1): 33–58.

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