Author:
Evseenko D.,Dundarov Z.,Galitskaya Y.
Abstract
In the scientific literature, there are no complete scientifically substantiated conclusion about the functional state of the antioxidant status of the skin, its scars and the possibilities of their local correction as part of complex therapy. We have analyzed the literature data reflecting the issues of complex therapy of cicatricial changes in the skin in order to determine the feasibility for the effective use of antioxidants in the local correction of oxidative stress disorders. The pathophysiological aspects of free radical mechanisms of skin scar formation have been studied. The cell pool that forms the skin, as a result of tissue respiration, continuously produces free radicals. Both external and internal environmental factors can lead to disruption of the dynamic balance in the body's natural antioxidant defense system, reducing the potential of its biological capacity. The phospholipid layer of the cell membrane, nuclear and mitochondrial DNA can be exposed to aggressive action of free radicals, thereby causing or aggravating the existing pathology of the skin. Reduced biological activity of enzymatic and non-enzymatic components of the body's antioxidant defense system does not properly lead to the deactivation of free radicals, which requires other approaches to local therapy.
Publisher
Republican Scientific and Practical Center for Radiation Medicine and Human Ecology
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