Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor
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Published:2020-05-19
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ISSN:1877-9352
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Container-title:Italian Journal of Medicine
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language:
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Short-container-title:Ital J Med
Author:
Alletto Maurizio,Burgio Antonio,Fulco Giovanni,Geraci Giulio,Groppuso Concetta,Gruttadauria Gianfranco,Manfrè Elvio,Mastrosimone Gianluca,Salvaggio Susanna,Urrico Giovanni,Vancheri Federico
Abstract
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, mainly localized in the stomach. Most GIST derive from mutations in tyrosine kinase receptors (KIT) or platelet-derived growth factor receptor-α (PDGFRA). GISTs are rarely associated with paraneoplastic hypoglycemia caused by non-β-cells tumor. This syndrome, defined non-islet cell tumor hypoglycemia (NICTH), arises from excess tumor production of insulin-like growth factor. We describe a 67-year-old female with severe NICTH secondary to an advanced and metastatic GIST.
Publisher
PAGEPress Publications