High Grade Leiomyosarcoma Mimicking a Recurrent Angiomyxoma in the Perineum

Author:

Sood Neha1,Swaika Abhisek2,Hanooshi Bashar3,Waldorf James4,Peterson Jennifer5,Wu Kevin6,Attia Steven2,Dinh Tri A.1

Affiliation:

1. Department of Medical and Surgical Gynecology, Mayo Clinic Florida, Jacksonville, FL, USA

2. Department of Medicine, Mayo Clinic Florida, Jacksonville, FL, USA

3. Department of Obstetrics and Gynecology, Flushing Hospital Medical Center, New York City, NY, USA

4. Department of Plastic Surgery, Mayo Clinic Florida, Jacksonville, FL, USA

5. Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA

6. Department of Pathology, Mayo Clinic Florida, Jacksonville, FL, USA

Abstract

Perineal leiomyosarcoma is an extremely rare and aggressive cancer with a high metastatic potential and no defined standard treatment. There are only a few (six) reported cases in the literature. We report the case of a 67-year-old woman with a perineal leiomyosarcoma arising at the same site of a previously resected superficial angiomyxoma. Initially, she was treated for a presumptive recurrence of angiomyxoma. As she did not respond to medical therapy, she underwent repeat surgical excision. Pathology revealed a high grade leiomyosarcoma, histologically strikingly distinct from the initial diagnosis. She received adjuvant local radiation therapy, and remains without evidence of recurrent disease 36 months after completion of all therapy. This is the first reported case of a high grade perineal leiomyosarcoma originating at the same site as a resected benign superficial angiomyxoma. Our case emphasizes the necessity of a prompt histological diagnosis in cases of presumed recurrent perineal angiomyxoma.

Publisher

SAGE Publications

Subject

Oncology,Histology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Rare case of giant ischiorectal leiomyosarcoma;International Journal of Surgery Case Reports;2024-08

2. Diagnostics and treatment of aggressive angiomyxoma;Oncology in Clinical Practice;2024-04-08

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