Optimizing stimulus repetition rate for recording ocular vestibular evoked myogenic potential elicited by air-conduction tone bursts of 500 Hz

Abstract

Amidst several publications reporting the effects of stimulus-related parameters on ocular vestibular evoked myogenic potential (oVEMP), the effect of the repetition rate on oVEMP responses has largely gone unexplored. Studies have used a repetition rate of ~5.1 Hz mainly due to a presumption that oVEMP, like cervical VEMP, should produce best responses for ~5 Hz, although there is paucity of experimental evidence to support this hypothesis. 52 healthy individuals in the age range of 17-35 years underwent air-conduction oVEMP elicited by 500 Hz tone-bursts using seven different repetition rates (3.1, 5.1, 10.1, 15.1, 20.1, 25.1 and 30.1 Hz). The results revealed a tendency for prolongation of latencies and reduction in amplitude with increasing repetition rate. However, significantly longer latencies were observed only for 20.1 Hz and larger amplitudes for 3.1 and 5.1 Hz (P<0.05). There was no significant difference between the rates of 3.1 Hz and 5.1 Hz. However 3.1 Hz produced poorer signal-to-noise ratio and required considerably longer time and thereby had lesser efficiency than 5.1 Hz (P<0.05). This would also result in higher fatigue and irritation levels considering the physical act of maintaining a supero-medial gaze. Thus the use of 5.1 Hz is recommended for clinical recording of oVEMP.