A rare case report of post-Covid Mucormycosis-Aspergillosis co-infection

Abstract

Background and Purpose: Mucormycosis and Aspergillosis square measure the foremost frequent fungal infections caused by these filiform fungi. Coinfection is scarce and incorporates a poor prognosis. The commonest presentation of invasive fungal infection (IFI) is rhinocerebral involvement. It ordinarily affects immunocompromised patients. Case report: A 55-year-old post-COVID male patient with uncontrolled Diabetes Mellitus developed swelling and chemosis in the left eye. In plain CT orbit, mucosal thickenings were seen in the ethmoid, sphenoid, left frontal, and left maxillary sinuses without any erosions or extensions. Nasal endoscopy showed black-brown overgrowth on the left middle turbinate. Biopsy revealed growth of both Mucor and Aspergillus. The patient was treated for Diabetic Ketoacidosis along with Amphotericin-B for anti-fungal management and showed significant improvement and is stable. Conclusion: It is probably the first rare case of coinfection with Mucormycosis (Rhizopus spp.) and Aspergillosis (Aspergillus flavus). Early diagnosis is a major advantage in management. The multidisciplinary approach of such cases is invaluable. The implementation of higher diagnostic methods including PCR in the diagnosis at all tertiary care facilities. A refined selection of post-COVID cases in higher numbers and cautious collection and processing of patient specimens will certainly attribute to higher chances of a definitive diagnosis and an early initiation of specific and efficient treatment.