A case of <em>Pneumocystis jirovecii</em> pneumonia in a patient with acquired immune deficiency syndrome who showed eosinophilia and an increased serum TARC/CCL17 level-Reference-Cited by-同舟云学术

A case of <em>Pneumocystis jirovecii</em> pneumonia in a patient with acquired immune deficiency syndrome who showed eosinophilia and an increased serum TARC/CCL17 level

Published:2022-01-12 Issue: Volume:17 Page:
ISSN:2049-6958
Container-title:Multidisciplinary Respiratory Medicine
language:
Short-container-title:Multidis Res Med

Author:

Yabuuchi Yuki^ORCID,Matsuyama Masashi^ORCID,Matsumura Sosuke,Nakajima Masayuki^ORCID,Kiyasu Yoshihiko,Takeuchi Yuto,Murata Yoshihiko,Matsuoka Ryota,Noguchi Masayuki,Hizawa Nobuyuki

Abstract

Pneumocystis jirovecii pneumonia (PCP) in patients with acquired immune deficiency syndrome (AIDS) shows eosinophilic pneumonia like condition. The detailed mechanisms how AIDS-associated PCP causes eosinophilic pneumonia has not been elucidated, but it has been suggested that beta-D-glucan, a major component of Pneumocystis jirovecii, and T helper type 2 immunity may be involved in the mechanism of eosinophilia in the lung. We experienced the case who developed an eosinophilic pneumonia-like condition in a patient with AIDS-associated PCP, whose clinical course indicated the importance of TARC/CCL17 but not IL-4 and IL-5 as involved in eosinophilia caused by HIV and Pneumocystis jirovecii infection.

Publisher

PAGEPress Publications

Subject

Pulmonary and Respiratory Medicine

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