Benign fasciculations and Corticosteroid use: possible association? An update

Author:

Orsini Marco,Sztajnbok Flavio R.,Oliveira Acary Bulle,Araújo Leite Marco Antonio,Salem Júnior Peter,De Freitas Marcos R.G.,Nascimento Osvaldo J.M.,Silva Júlio Guilherme,Puccioni Sholer Marzia,Silva Guimarães Fernando,Cardoso Pereira Alessandra,Silveira de Menezes Sara Lúcia,Da Silva Catharino Antonio Marcos,Bino Fabrício

Abstract

Fasciculations are characterized by visible subtle and fast contractions of muscle, even wormlike in movement, by the contraction of a fascicle of muscle fibers. The authors present the case study of a 28-year-old patient with the appearance of migratory and diffuse fasciculations with an onset after partial tapering off of oral corticosteroides (60 mg total dose) indicated for treatment of Minimal change Glomerulopathy. Clinical Neurological physical exam allied with an ENMG, besides other complementary laboratory exams were used for screening the above-mentioned patient. Afterwards, current research relating to the topic at hand was made in order to update the data available in the Bireme, Scielo and PubMed Data Banks using the following key words: Fasciculation’s, motor neuron disease, and benign fasciculations in the Portuguese, English as well as Spanish language. Although fasciculation’s are most commonly associated with Motor neuron disease as well as with certain metabolic disorders, they may also be present in individuals with absolutely no underlying pathological disorders. In our case, fasciculation potentials that have been present for six months, with no other signs of a neurogenic disorder as well as absence of laboratory findings, the patient received a diagnosis of Benign Fasciculation Syndrome (BFS).We believe that the use of corticosteroides in high doses with subsequent tapering contributed to the fasciculation’s, especially due to the changes that this causes on the ionic channels. Fasciculation’s are symptoms seen in a large range of conditions, and also being the main symptom of the so-called Benign Fasciculation Syndrome. We have presented an example of this clinical syndrome in a patient whose complaint was fasciculation’s, with complete clinical remission of symptoms following complete tapering off of corticosteroid six months previously.

Publisher

MDPI AG

Subject

Clinical Neurology

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Muskelzuckungen und Muskelkrämpfe – Differenzialdiagnosen und elektrophysiologische Diagnostik;Klinische Neurophysiologie;2023-03

2. Acupuntura No Tratamento Do Lúpus Eritematoso Sistêmico: Revisão De Literatura;Revista Científica Multidisciplinar Núcleo do Conhecimento;2021-06-29

3. Das Myalgie-Faszikulations-Krampus-Syndrom (MFKS);Fortschritte der Neurologie · Psychiatrie;2020-07

4. Benign Fasciculation Syndrome;Journal of Pain & Palliative Care Pharmacotherapy;2015-01-02

5. Another perspective on fasciculations: when is it not caused by the classic form of amyotrophic lateral sclerosis or progressive spinal atrophy?;Neurology International;2014-08-08

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