Daily Living Skills in Adolescent and Young Adult Males With Fragile X Syndrome

Author:

Thurman Angela John1,Swinehart Stephanie Summers1,Klusek Jessica2,Roberts Jane E.2,Bullard Lauren3,Marzan Jocelyn Christina B.4,Brown W. Ted5,Abbeduto Leonard6

Affiliation:

1. Angela John Thurman and Stephanie Summers Swinehart, University of California Davis Health

2. Jessica Klusek and Jane E. Roberts, University of South Carolina

3. Lauren Bullard, University of California Davis Health

4. Jocelyn Christina B. Marzan, University of the Philippines—Manila, Philippines

5. . Ted Brown, University of Sydney and NYS Institute for Basic Research

6. Leonard Abbeduto, University of California Davis Health

Abstract

Abstract By adulthood, most males with fragile X syndrome (FXS) require support to navigate day-to-day settings. The present study cross-sectionally: (1) characterized the profile of daily living skills in males with FXS and (2) examined associated participant characteristics (i.e., fragile X mental retardation protein [FMRP] expression, nonverbal cognition, language, autism symptomatology, and anxiety symptomatology) using the Waisman-Activities of Daily Living questionnaire. Males with FXS (n = 57, ages 15–23 years) needed more help/support in the areas of domestic and community daily livings skills, than in the area of personal daily living skills. Significant associations were observed between reduced daily living skills and lower nonverbal cognition, receptive language, expressive language, and increased autism symptomatology. Receptive language emerged as the strongest unique predictor of daily living skill performance.

Publisher

American Association on Intellectual and Developmental Disabilities (AAIDD)

Subject

Psychiatry and Mental health,Neurology (clinical),Arts and Humanities (miscellaneous),Developmental and Educational Psychology,Neuropsychology and Physiological Psychology,General Medicine,Pediatrics, Perinatology and Child Health

Reference74 articles.

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2. Abbeduto, L., McDuffie, A. S., & Thurman,A. J. (2014). The fragile X syndrome-autism comorbidity: What do we really know?Frontiers in Genetics, 5.https://doi.org/10.3389/fgene.2014.00355

3. Abbeduto, L., McDuffie, A. S., Thurman, A. J., & Kover,S. T. (2016). Language development in individuals with intellectual and developmental disabilities: From phenotypes to treatments. In International Review of Research in Developmental Disabilities, 50, 71– 118. https://doi.org/10.1016/bs.irrdd.2016.05.006

4. Abbeduto, L., Thurman, A. J., McDuffie, A., Klusek, J., Feigles, R. J. Brown, W. T. Harvey, D.J., Adayev, T., LaFauci, G., Dobkins, C., & Roberts,J. (2019). ASD Comorbidity in fragile X syndrome: Symptom profile and predictors of symptom severity in adolescent and young adult males. Journal of Autism and Developmental Disorders, 49, 960– 977. https://doi.org/10.1007/s10803-018-3796-2

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