Affiliation:
1. Voronezh State University
2. Joint Vietnam-Russia Tropical Science and Technology Research Center, Coastal Branch
Abstract
The study touches the development of piezoelectric sensors based on molecularly imprinted polymers (MIPs) with an aspartame imprint. The values of the imprinting factors and the selectivity coefficients of the developed sensor MIP-E951 in relation to target molecules and other sweeteners were calculated to confirm the ability of MIP -951 to selective detection of aspartame. The range of determined concentrations is 1 – 1 × 10–3 g/liter, the detection limit of aspartame is 5 × 10–4 g/liter. When analyzing model solutions, it was found that foreign components usually present in soft drinks do not interfere with the determination of aspartame using the developed sensor. The obtained sensors were tested for the determination of aspartame in soft drinks. Chromatographic analysis was used as a reference method. The results obtained by both methods indicate that piezo sensors can be successfully used for the analysis of aspartame in liquid media. The error of determination does not exceed 8%.
Reference17 articles.
1. Gromova O. A., Rebrov V. G. Sweeteners. Effecteveness and safety of application / Trudnyi Patsient. 2007. Vol. 5. N 12 – 13. P. 47 – 49 [in Russian].
2. Santos N. C., De Araujo L. M., De Luca G. C., et al. Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials / Crit. Rev. Food Sci. Nutr. 2018. Vol. 58. N 12. P. 2068 – 2081. DOI: 10.1080/10408398.2017.1304358
3. Hu H., Zhang P., Yin J., et al. The effect of aspartame on accelerating caspase-dependent apoptosis of pancreatic islet via ZIPK/STAT3/caspase 3 signaling pathway / J. Physiol. Biochem. 2024. Vol. 80. P. 53 – 65. DOI: 10.1007/s13105-023-00980-2
4. Landrigan P. J., Straif K. Aspartame and cancer — new evidence for causation / Environ. Health (London, UK). 2021. Vol. 20. P. 1 – 5. DOI: 10.1186/s12940-021-00725-y
5. Kazantsev A. V., Makhon’ko M. N. Sweet non-alcoholic carbonated drinks of modern production and diseases caused by their drinking / Byull. Med. Internet-Konf. 2014. Vol. 4. N 11. P. 1253 – 1256 [in Russian].