Chronic Pancreatitis, Comorbid with Alcohol Addiction: Epidemiology, Causes, Developmental Features, Symptoms and Supportive Pharmaceutical Therapy

Abstract

Chronic pancreatitis is a chronic inflammatory disease of the pancreas, which is accompanied by irreversible structural changes in the development of excretory and incretory insufficiency, manifested by abdominal pain and characterized by a significant reduction in the quality of life of patients. Purpose of the study was to determine the place of alcoholic (toxic) chronic pancreatitis among pancreatitis; to systematize scientific sources on the role of psychoactive substances in the development of comorbid chronic pancreatitis with alcohol addiction. In the period from 1997 to 2021, a review of the scientific literature on the topic of the work was conducted. Depending on the region, up to 70% of acute pancreatitis and up to 90% of chronic pancreatitis cases are alcohol-related psychoactive substances. Alcoholic (toxic) pancreatitis occurs due to exposure of the pancreas to alcohol in up to 80% of all cases. Pharmacotherapy of chronic pancreatitis is important in the context of the spread of coronavirus infection, in most cases conservative, is carried out taking into account the causes and risk factors. Scientific sources on the topic of the work are systematized. Literature data on the epidemiology, causes of chronic pancreatitis and the role of psychoactive substances in the development of chronic pancreatitis were studied.