Proton Therapy in the Treatment of Anal Cancer in Pelvic Kidney Transplant Recipients: A Case Series

Author:

Buchberger David1,Kreinbrink Paul1,Kharofa Jordan1

Affiliation:

1. Department of Radiation Oncology, University of Cincinnati Medical Center, Cincinnati, OH, USA

Abstract

Abstract Purpose: The incidence of anal cancer in patients with kidney transplants has increased. The definitive treatment for anal cancer is chemotherapy and intensity-modulated radiation therapy. In kidney transplant recipients, sparing the pelvic kidney in the process of delivering radiation to the anus can be challenging. Intensity-modulated proton therapy (IMPT) has been proposed as an alternative to intensity-modulated radiation therapy for the treatment of anal cancer in this population, given its increased ability to spare organs-at-risk. Case Series: We present 4 cases of patients with transplanted pelvic kidneys who subsequently developed anal cancer and were treated with IMPT from 2017 to 2019. Conclusion: Use of IMPT appears to be an acceptable option for the treatment of anal cancer in patients with a pelvic kidney.

Publisher

International Journal of Particle Therapy

Subject

Radiology, Nuclear Medicine and imaging,Atomic and Molecular Physics, and Optics

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