Consensus Statement on Proton Therapy for Prostate Cancer

Author:

Bryant Curtis M.1,Henderson Randal H.1,Nichols R. Charles1,Mendenhall William M.1,Hoppe Bradford S.2,Vargas Carlos E.3,Daniels Thomas B.3,Choo C. Richard4,Parikh Rahul R.5,Giap Huan6,Slater Jerry D.7,Vapiwala Neha8,Barrett William9,Nanda Akash10,Mishra Mark V.11,Choi Seungtaek12,Liao Jay J.13,Mendenhall Nancy P.1,

Affiliation:

1. Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA

2. Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL, USA

3. Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, USA

4. Department of Radiation Oncology, Mayo Clinic Rochester, Rochester, MN, USA

5. Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA

6. Department of Radiation Oncology, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL, USA

7. Department of Radiation Oncology, Loma Linda University, Loma Linda, CA, USA

8. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA

9. Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA

10. Department of Radiation Oncology, Orlando Health, Orlando, FL, USA

11. Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA

12. Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

13. Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA, USA

Abstract

Abstract Proton therapy is a promising but controversial treatment in the management of prostate cancer. Despite its dosimetric advantages when compared with photon radiation therapy, its increased cost to patients and insurers has raised questions regarding its value. Multiple prospective and retrospective studies have been published documenting the efficacy and safety of proton therapy for patients with localized prostate cancer and for patients requiring adjuvant or salvage pelvic radiation after surgery. The Particle Therapy Co-Operative Group (PTCOG) Genitourinary Subcommittee intends to address current proton therapy indications, advantages, disadvantages, and cost effectiveness. We will also discuss the current landscape of clinical trials. This consensus report can be used to guide clinical practice and research directions.

Publisher

International Journal of Particle Therapy

Subject

Radiology, Nuclear Medicine and imaging,Atomic and Molecular Physics, and Optics

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