Anti-inflammatory and Radical Scavenge Effects of Arctium lappa

Author:

Lin Chun-Ching1,Lin Jer-Min2,Yang Jeng-Jer1,Chuang Shu-Chuan1,Ujiie Takashi3

Affiliation:

1. Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan

2. Ziel Enterprise Co., Ltd. Kaohsiung, Taiwan

3. Japan Food Research Laboratories, Nagoya Branch, Oosu Naka-ku, Nagoya, 460, Japan

Abstract

The effects of Arctium lappa L. (root) on anti-inflammatory and free radical scavenger activity were investigated. Subcutaneous administration of A. lappa crude extract significantly decreased carrageenan-induced rat paw edema. When simultaneously treated with CCl4, it produced pronounced activities against CCl4-induced acute liver damage. The free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (ESR) spectrometer. The IC50 of A. lappa extract on superoxide and hydroxyl radical scavenger activity was 2.06 mg/m 11.8 mg/m1, respectively. These findings suggest that Arctium lappa possess free radical scavenging activity. The inhibitory effects on carrageenan-induced paw edema and CCl4-induced hepatotoxicity could be due to the scavenging effect of A. lappa.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

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