Affiliation:
1. Pain Research Laboratory, Tsumura & Co., 3586 Yoshiwara, Ami-machi, lnashiki -gun, Ibaraki-ken, 300-11, Japan
Abstract
The anti-nociceptive effect of processed aconiti tuber (TJ-3021), one of the traditional oriental herbal medicines (Kampo), was investigated by utilizing various methods including repeated cold stress and adjuvant articular inflammation in rats and mice. Analgesic potency was compared with that of mesaconitine, a potent component of aconitine alkaloids, and other analgesic agents. It was found that mesaconitine was more potent than morphine, and a processed aconiti tuber [(TJ-3021), Tsumura-shuchi-bushi-matsu] showed some analgesic effect, although it was weaker than those of dichlofenac, aminopyrine and indomethacine.
Publisher
World Scientific Pub Co Pte Lt
Subject
Complementary and alternative medicine,General Medicine
Cited by
31 articles.
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