Vandellia CordifoliaRegulated Cell Proliferation and Cytokines Production in Human Mononuclear Cells-Reference-Cited by-同舟云学术

Vandellia CordifoliaRegulated Cell Proliferation and Cytokines Production in Human Mononuclear Cells

Published:2000-01 Issue:03n04 Volume:28 Page:313-323
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Lin An-Pang¹,Tsai Wei-Jern²,Fan Chi-Yen¹,Lee Ming-Jen¹,Kuo Yuh-Chi²³

Affiliation:

1. Jen Ai Chinese Medical United Clinical, Taipei, Taiwan

2. National Research Institute of Chinese Medicine, Taipei, Taiwan

3. Institute of Biology, Fu-Jen University, Taipei, Taiwan

Abstract

Vandellia cordifolia (V. cordifolia) used for treatment inflammation in traditional Chinese medicine was selected for immunopharmacological activity test. The effects of V. cordifolia extracted fractions on human mononuclear cells (HMNC) proliferation were determined by tritiated thymidine uptake. The results indicated that VC-ME fraction suppressed HMNC proliferation activated with phytohemagglutinin (PHA) and stimulated cell cycle progression was arrested at the G0/G1 stage. The inhibitory mechanisms may involve the blocking of interleukin-2 (IL-2) and interferon-γ (IFN-γ) production, since VC-ME suppressed IL-2 and IFN-γ production of HMNC in a dose-dependent manner. Therefore, it is suggested that immunomodulatory agents are contained in V. cordifolia.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X00000374

Reference15 articles.

1. The Cell Biology of Macrophage Activation

2. Human tumor necrosis factor. Production, purification, and characterization.

3. IL-6 and NF-IL6 in Acute-Phase Response and Viral Infection

4. Non-Parasite-Specific Cytokine Responses may Influence Disease Outcome following Infection

5. CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches;Pharmaceuticals;2020-08-06

2. Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2;Oxidative Medicine and Cellular Longevity;2017

3. Oxidative Stress, Prooxidants, and Antioxidants: The Interplay;BioMed Research International;2014

4. In vitro activity of labdane diterpene from Alomia myriadenia (Asteraceae): immunosuppression via induction of apoptosis in monocytes;International Immunopharmacology;2003-03