The Inhibitory Effect of Herbal Medicine -Dai Kenchu To (DKT)- on the Colonic Motility in Rats In Vitro-Reference-Cited by-同舟云学术

The Inhibitory Effect of Herbal Medicine -Dai Kenchu To (DKT)- on the Colonic Motility in Rats In Vitro

Published:2001-01 Issue:01 Volume:29 Page:111-118
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Tulimat Mohammad Alhakam¹,Ishiguchi Tadashi¹,Kurosawa Susumu²,Nakamura Takashi²,Takahashi Toku¹

Affiliation:

1. Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, Japan

2. The Third Department of Internal Medicine, Teikyo University, Chiba, Japan

Abstract

Dai-Kenchu-To (DKT) is a herbal medicine and is currently used as the treatment of paralytic ileus in Japan. We investigated the mechanism of beneficial effects of DKT in vitro. DKT-extract powder (DKT-EP; 30–300 μg/ml) caused a significant inhibition on carbachol (CCH; 10-6)-induced contraction in a concentration dependent manner of the rat distal colon. DKT-EP (100 μg/ml) consists of 20 μg/ml of Zanthoxylum Fruit, 30 μg/ml of Ginseng Root and 50 μg/ml of Ginger Rhizome. Although each of them had no effect on CCH-induced muscle contraction, the combination of three ingredients caused a significant inhibition on CCH-induced contraction.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X01000125

Reference14 articles.

1. An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover

2. Relaxation of Isolated Gastric Smooth Muscle Cells by Vasoactive Intestinal Peptide

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