The Neuroprotective Effect of Picroside II from Hu-Huang-Lian against Oxidative Stress

Author:

Li Ting1,Liu Jian-Wen1,Zhang Xiao-Dong1,Guo Ming-Chuan1,Ji Guang2

Affiliation:

1. The State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, China

2. Laboratory of Liver Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China

Abstract

Picroside II is an active constituent extracted from the traditional Chinese medicine (TCM) Hu-Huang-Lian. To evaluate the neuroprotective effect of picroside II, PC12 cells were treated with glutamate in vitro and male ICR mice were treated with AlCl 3in vivo. Pre-treatment of PC12 cells with picroside II could enhance the cell viability and decrease the level of intracellular reactive oxygen species (ROS) induced by glutamate. By DNA fragmentation and flow cytometry assay, picroside II (1.2 mg/ml) significantly prevented glutamate-induced cell apoptosis. In the animal study, amnesia was induced in mice by AlCl 3 (100 mg/kg/d, i.v.). Pricroside II, at the dose of 20 and 40 mg/kg/d (i.g.), markedly ameliorated AlCl 3-induced learning and memory dysfunctions and attenuated AlCl 3-induced histological changes. This was associated with the significant increased superoxide dismutase (SOD) activity in the brain of experimental mice. All these results indicated that picroside II possessed the therapeutic potential in protecting against neurological injuries damaged by oxidative stress.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

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