Effect of Three Japanese Kampo Medicines on Platelet Activation by Monoclonal Anti-platelet Membrane Glycoprotein Antibodies
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Published:1994-01
Issue:01
Volume:22
Page:71-76
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ISSN:0192-415X
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Container-title:The American Journal of Chinese Medicine
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language:en
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Short-container-title:Am. J. Chin. Med.
Author:
Kawakatsu Toshihiro1,
Nomura Shosaku1,
Kido Hirofumi1,
Yamaguchi Kazuyuki1,
Fukuroi Tsutomu1,
Suzuki Masahiko1,
Yanabu Mutsumasa1,
Kokawa Terutoshi1,
Yasunaga Kojiro1
Affiliation:
1. First Department of Internal Medicine, Kansai Medical University, 1 Fumizono-cho, Moriguchi, Osaka 570, Japan
Abstract
We studied the effect of three Japanese kampo medicines on platelet activation by an anti-CD9 monoclonal antibody (NNKY1-19) and an anti-human Fc gamma receptor II monoclonal antibody (NNKY3-2). Sho-saiko-to (TJ-9) and Sairei-to (TJ-114) partially suppressed platelet aggregation induced by NNKYl-19, while Juzen-taiho-to (TJ-48) suppressed aggregation induced by NNKY3-2. TJ-9 and TJ-114 also suppressed collagen-induced aggregation, but TJ-48 did not. Flow cytometry showed that the three medicines did not affect antibody binding to the platelets. Thus, all three kampo medicines suppressed platelet activation by anti-platelet glycoprotein antibodies without inhibiting antibody binding.
Publisher
World Scientific Pub Co Pte Lt
Subject
Complementary and alternative medicine,General Medicine
Cited by
1 articles.
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