Aldose Reductase Inhibitors fromViola hondoensisW. Becker et H Boss-Reference-Cited by-同舟云学术

Aldose Reductase Inhibitors fromViola hondoensisW. Becker et H Boss

Published:2008-01 Issue:04 Volume:36 Page:799-803
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Chung Ill-Min¹,Kim Min-Young¹,Park Won-Hwan²,Moon Hyung-In³

Affiliation:

1. Department of Applied Life Science, Kon Kuk University, Seoul, 143-701, South Korea

2. Department of Diagnostics, College of Korean Medicine and Cardiovascular Medical Research Center, Dongguk University, Gyeong-Ju 780-714, South Korea

3. Department of Neuroscience and Inam Neuroscience Research Center, Sanbon Medical Center, Wonkwang University, Gunpo-city, Kyunggido, 435-040, South Korea

Abstract

The isolation and characterization of rat lens aldose reductase inhibitors from the Viola hondoensis W. Becker et H Boss were conducted. The extracts and organic fractions from V. hondoensis were tested. The MeOH extract and EtOAc fraction were found to exhibit potent rat lens aldose reductase inhibition in vitro, their IC50being 1.2 and 0.6 μg/ml, respectively. One major isoflavonoid glycoside was isolated from the ethyl acetate soluble fraction of V. hondoensis. Kakkalide was found to be the potential rat lens aldose reductase inhibitor (IC50= 0.34 μg/ml), and may be useful for the prevention and/or treatment of diabetic complications.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X08006247

Reference14 articles.

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2. Isolation and Properties of Lens Aldose Reductase

3. Rat Lens Aldose Reductase Inhibitory Activities of Coptis japonica Root-Derived Isoquinoline Alkaloids

4. Y. Lee, Flora of Korea (Hyang-Mun-Sa, South Korea, 1996) p. 287.

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