Effects of Ryo-Kan-Kyomi-Sin-Ge-Nin-To Extract on Degranulation of and Histamine Release from Rat Mast Cells-Reference-Cited by-同舟云学术

Effects of Ryo-Kan-Kyomi-Sin-Ge-Nin-To Extract on Degranulation of and Histamine Release from Rat Mast Cells

Published:1991-01 Issue:03n04 Volume:19 Page:243-249
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Shibata Tadayoshi¹,Kono Takeshi²,Tanii Tsukasa²,Mizuno Nobuyuki²,Hamada Toshio²

Affiliation:

1. Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, Osaka 537, Japan

2. Department of Dermatology, Osaka City University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka 545, Japan

Abstract

The effects of Ryo-kan-kyomi-sin-ge-nin-to (RKSG) extract, a medicinal agent traditionally used in China and Japan for treatment of asthma, on the degranulation of and histamine release from rat mast cells were studied. At a concentration of 5 mg/ml RKSG, degranulation of mast cells stimulated either by antigen (DNP-Ascaris) or compound 48/80 was markedly suppressed. At a concentration of 1-5 mg/ml RKSG, histamine release from mast cells due to application of either antigen or compound 48/80 was inhibited in a dose-dependent fashion. These results suggest that RKSG may be useful for the treatment of type I allergy-related diseases.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X91000326

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