Application of Chinese Medicine in the Management of Critical Conditions: A Review on Sepsis

Author:

Fan Tian-Tian1,Cheng Bao-Li2,Fang Xiang-Ming2,Chen Yong-Can3,Su Fan4

Affiliation:

1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China

2. Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, P. R. China

3. Gastroenterology of Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou 310007, P. R. China

4. Department of Anesthesiology, Affiliated Hospital of Shandong, University of Traditional Chinese Medicine, Jinan 250014, P. R. China

Abstract

Critical care medicine is a medical specialty engaging the diagnosis and treatment of critically ill patients who have or are likely to have life-threatening organ failure. Sepsis, a life-threatening condition that arises when the body responds to infection, is currently the major cause of death in intensive care units (ICU). Although progress has been made in understanding the pathophysiology of sepsis, many drawbacks in sepsis treatment remains unresolved. For example, antimicrobial resistance, controversial of glucocorticoids use, prolonged duration of ICU care and the subsequent high cost of the treatment. Recent years have witnessed a growing trend of applying traditional Chinese medicine (TCM) in sepsis management. The TCM application emphasizes use of herbal formulation to balance immune responses to infection, which include clearing heat and toxin, promoting blood circulation and removing its stasis, enhancing gastrointestinal function, and strengthening body resistance. In this paper, we will provide an overview of the current status of Chinese herbal formulations, single herbs, and isolated compounds, as an add-on therapy to the standard Western treatment in the sepsis management. With the current trajectory of worldwide pandemic eruption of newly identified Coronavirus Disease-2019 (COVID-19), the adjuvant TCM therapy can be used in the ICU to treat critically ill patients infected with the novel coronavirus.

Funder

National Key Research and Development Program of China

the National Natural Science Foundation of China

Natural Science Foundation of Shandong Province, China

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

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