Differential Gene Expression in Hemodialysis Patients with "Cold" Zheng-Reference-Cited by-同舟云学术

Differential Gene Expression in Hemodialysis Patients with "Cold" Zheng

Published:2006-01 Issue:03 Volume:34 Page:377-385
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Chen Chia-Sheng¹,Lin Li-Wei²,Hsieh Chia-Chang³,Chen Guang-Wei¹,Peng Wen-Huang²,Hsieh Ming-Tsuen²

Affiliation:

1. Institute of Chinese Medical Sciences, China Medical University, 91 Hsueh Shih Road, Taichung 404, Taiwan, R.O.C.

2. Institute of Chinese Pharmaceutical Sciences, China Medical University, 91 Hsueh Shih Road, Taichung 404, Taiwan, R.O.C.

3. School of Medicine, Kyorin University, Tokyo, Japan, and Jen-Te Junior College of Medicine, Nursing and Management, Miaoli, Taiwan, R.O.C.

Abstract

The aim of the present study was to search for the differential gene expression and measure the serum level of a number of biochemical parameters in the cold Zheng (CZ) and non-cold Zheng (NCZ) in patients receiving hemodialysis. Hemodialysis (HD) patients were randomly selected from the CZ and NCZ groups. The between-group differences in gene expression were assessed using complementary DNA (cDNA) microarray. Differential gene expression was further validated by real-time reverse transcriptase polymerase chain reaction (RT-PCR). Our results demonstrated that the up-regulation of the inflammation-associated genes, ALOX5AP, S100A8 and S100A12, down-regulation of the genes related to immunity (DEFA4), metabolism (GNG11, PYGB, PRKAR2B), and growth/proliferation (HSF2, DDR2, TK1) were found in the CZ group. Furthermore, the CZ HD patients had significantly lower serum albumin levels compared with their NCZ counterparts (3.31 ± 0.08 g/dL versus 4.18 ± 0.12 g/dL ). It appears reasonable to conclude that up-regulated inflammatory-gene expression (ALOX5AP, S100A8 and S100A12) may play an important role in CZ HD patients.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X06003916

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