Preventive and Therapeutic Effects of Ginsenoside Rb1 for Neural Injury During Cerebral Infarction in Rats-Reference-Cited by-同舟云学术

Preventive and Therapeutic Effects of Ginsenoside Rb1 for Neural Injury During Cerebral Infarction in Rats

Published:2013-01 Issue:02 Volume:41 Page:341-352
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Jiang Zhou¹,Wang Yuhui¹,Zhang Xiaoyun²,Peng Tao²,Lu Yun²,Leng Jianchun²,Xie Quan²

Affiliation:

1. Key Laboratory of Chronobiology, Ministry of Health (Sichuan University), Sichuan University, Chengdu, Sichuan 610041, P. R. China

2. Teaching Hospital of Chengdu, University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, P. R. China

Abstract

To examine the preventive and therapeutic effects of ginsenoside Rb1 for neural injury during cerebral infarction, we used a middle cerebral artery occlusion (MCAO) model in rats to investigate the effects of ginsenoside Rb1 with Edaravone as a control. Ginsenoside Rb1 was given to the rats by intragastric administration either before or after the MCAO surgery to study its preventive and therapeutic effects. Ginsenoside Rb1-treated rats had a smaller infarct volume than the positive control. Interleukin-1 (IL-1), brain-derived neurotrophic factor (BDNF), tumor necrosis factor-α (TNF-α), neurofilament (NF) and growth associated protein-43 (GAP-43) were measured to determine brain damage and the recovery of nerves. These findings suggest that ginsenoside Rb1 has neuroprotective effects in rats, and the protection efficiency is higher than Edaravone. The protective mechanism is different from Edaravone. The preventive ability of ginsenoside Rb1 is higher than its repair ability in neuroprotection in vivo.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X13500250

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