Affiliation:
1. Institute of Botany (Nanjing Botanical Garden, Mem. Sun Yet-sen), Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, Jiangsu, China
Abstract
Folium Eriobotryae, dried leaves of Eriobotrya japonica (Thunb.) Lindl. is a traditional Chinese medicine with rich resources in China. This research investigated the anti-hyperglycemic effect of Folium Eriobotryae on normal and alloxan-diabetic mice. The 70% ethanol extract of Folium Eriobotryae (EJA-0) in doses of 15, 30 and 60 g (crude drug)/kg exerted a significant hypoglycemic effect on alloxan-diabetic mice, among which 30 g/kg of EJA-0 was more effective than 100 mg/kg of phenformin. The total sesquiterpenes (EJA-1) 30 g (crude drug)/kg had significant effect on lowering blood glucose level in normal or/and alloxan-diabetic mice. The tests of maximum dosage and acute toxicity showed that EJA-1 was safe (MD = 360 g/kg, LD50 = 400.1 g/kg). The pharmacological tests on anti-hyperglycemic effects of EJA-0 and EJA-1 prove that Folium Eriobotryae is an outstanding material to develop medicine for treatment of diabetes mellitus.
Publisher
World Scientific Pub Co Pte Lt
Subject
Complementary and alternative medicine,General Medicine
Cited by
30 articles.
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