NEW PORPHYRIN ADDUCT OF FULLERENE-C60: A PROMISING NANOTOOL FOR MEDICINAL USE IN THE HEART MUSCLE HYPOXIA CASES

Abstract

This is a first case ever reported on the fullerene-based low toxic nanocationite particles (porphyrin adducts of cyclohexl fullerene- C60) designed for targeted delivery of the paramagnetic magnesium stable isotope to the heart muscle providing a sharp clinical effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24 h after a single injection (0.03–0.1 LD50). A whole principle of this therapy is novel:25Mg2+-magnetic isotope effect selectively stimulates the ATP over-production in the oxygen-depleted cell due to25Mg2+released by nanoparticles. Being membranotropic cationites, these "smart nanoparticles" release the over-activating paramagnetic cations only in response to the metabolic acidic shift. The resulting positive changes in the heart cell energy metabolism may help to prevent and/or treat the local myocardial hypoxic disorders and, hence, to protect the heart muscle from a serious damage in a vast variety of the hypoxia-caused clinical situations including both Doxorubicin and 1-methylnicotineamide cardiotoxic side effects. Both pharmacokinetics and pharmacodynamics of the drug proposed makes it suitable for safe and efficient administration in either single or multi-injection (acute or chronic) therapeutic schemes.