PREPARATION OF THE HONEYCOMB PATTERNED POROUS FILM OF BIODEGRADABLE POLYMER FOR TISSUE ENGINEERING SCAFFOLDS-Reference-Cited by-同舟云学术

PREPARATION OF THE HONEYCOMB PATTERNED POROUS FILM OF BIODEGRADABLE POLYMER FOR TISSUE ENGINEERING SCAFFOLDS

Published:2002-10 Issue:05n06 Volume:01 Page:689-693
ISSN:0219-581X
Container-title:International Journal of Nanoscience
language:en
Short-container-title:Int. J. Nanosci.

Author:

SATO KATSUHISA¹,HASEBE KIYOSHI¹,TANAKA MASARU²,TAKEBAYASHI MASAFUMI²,NISHIKAWA KAZUTAKA²,SHIMOMURA MASATSUGU²,KAWAI TOMOAKI³,MATSUSHITA MICHIAKI³,TODO SATORU³

Affiliation:

1. Graduate School of Environmental Earth Science, Hokkaido University, N10 W5, Kita-ku Sapporo, Hokkaido 060-0810, Japan

2. Research Institute for Electronic Science, Hokkaido University, N12 W6, Kita-ku Sapporo, Hokkaido 060-0812, Japan

3. Hokkaido University School of Medicine, N15W7, Kita-ku,Sapporo, Hokkaido 060-8648, Japan

Abstract

Fabrication and surface modification of a cell scaffold are very important in tissue engineering. In this study, the effects of pore size and surface wettability on hepatocyte adhesion and morphology was studied, using the porous poly-ε-caprolactone (PCL) film prepared by a simple casting technique. The degree of spreading of hepatocyte was enhanced with the decrease of the pore size (~10 μm). Hepatocyte motility and spreading were restricted on the patterned film having cellular-sized pores (ca. 20 μm). Partial hydrolysis of the film surface enhanced the migration and spheroid formation of the cultured hepatocyte.

Publisher

World Scientific Pub Co Pte Lt

Subject

Electrical and Electronic Engineering,Computer Science Applications,Condensed Matter Physics,General Materials Science,Bioengineering,Biotechnology

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0219581X02000905

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