SEMICONDUCTOR NANOPARTICLES AS REPORTERS IN MULTIPLEXED IMMUNOASSAY AND CELL ANALYSIS

Author:

DUBROVSKY TIM1

Affiliation:

1. Protein Chemistry and Reagents Group, BD Biosciences, 2350 Qume Drive, San Jose, California, CA 95131, USA

Abstract

The development of new fluorophores has experienced a tremendous advance over the last two decades. Here, we discuss the photophysical properties of traditional fluorescent labels and the comparatively advantageous properties of quantum dots. The unique spectral properties of quantum dots, such as their large Stokes shifts and exceptional brightness, make them attractive probes in biological applications and prime candidates for further research and development in the field of solid-phase immunoassay and cell analysis.

Publisher

World Scientific Pub Co Pte Lt

Subject

Electrical and Electronic Engineering,Computer Science Applications,Condensed Matter Physics,General Materials Science,Bioengineering,Biotechnology

Reference6 articles.

1. (CdSe)ZnS Core−Shell Quantum Dots:  Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites

2. Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo

3. B. Abrams and T. Dubrovsky, Methods in Molecular Biology, Vol. 374: Quantum Dots: Applications in Biology, eds. M. P. Bruchez and C. Z. Hotz (Humana Press, Totowa, NJ, 2006) pp. 185–203.

4. Cytokine flow cytometry: a multiparametric approach for assessing cellular immune responses to viral antigens

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