DIFFERENT ANGIOGENIC BEHAVIOUR OF LIGATED SAPHENOUS AND EPIGASTRIC VASCULAR BUNDLES IN AVASCULAR ENVIRONMENT: AN IN-VIVO EXPERIMENTAL STUDY

Abstract

The purpose of the study was to compare angiogenic response of isolated saphenous and epigastric arteriovenous bundles in avascular environment, in an in-vivo model. Saphenous and epigastric bundles of 20 rats were dissected and ligated distally. The bundles were implanted into silicone tubing to create a biologically neutral environment. Gross and histologic examination was performed at different intervals. No thrombus was detected in any of bundles prior to 24 hours. An adherent thrombus was seen at 24 hours in all ligated saphenous bundles; it persisted at three weeks with no evidence of neovascular sprouting. The ligated epigastric bundles remained patent with evidence of neovascular sprouting. The saphenous vessels are more likely to thrombose and do not show vascular proliferation when placed in an isolated environment, whereas the epigastric vessels are likely to remain patent and show vascular proliferation.