Comparative Study of Magnetic Properties and Antitumor Effect of Nanocomplexes from Oxides Iron Nanoparticles and Doxorubicin During Radio-Frequency Hyperthermia of the Walker-256 Carcinosarcoma

Abstract

A comparative study of magnetic properties using the method of magnetometry with vibration magnetometer and spectra of electron paramagnetic resonance (EPR) nanocomplexes (NCs) of nanoparticles Fe 2 O 3, Fe 3 O 4 and antitumor antibiotic doxorubicin (DOXO) have shown that changes in saturation magnetic moments are similar to changes in integral intensity of EPR spectra. The greatest magnetic moments of saturation and integral intensity of EPR spectra were demonstrated by samples of Fe 3 O 4 in NC with doxorubicin, which had the highest antitumor effect in radiofrequency hyperthermia of Walker-256 carcinosarcoma. The presented research provides the evidence of stronger antitumor effect of Fe 3 O 4 and DOXO NC in comparison to NC from γ- Fe 2 O 3 and DOXO at combined action of constant magnetic field and electromagnetic field. This can be a basis for development of bioengineering technology of magnetic cancer nanotherapy in conditions of moderate hyperthermia (< 39°C).