Investigation of Lanolin Lipid-Based Nanoparticles as Carriers for Avobenzone

Abstract

The aim of this study is to develop and characterize lanolin lipid-based nanoparticles as carriers for avobenzone. Solid Lipid nanoparticles (SLNs) were prepared by the high-pressure homogenization technique. The influence of emulsifiers, avobenzone content in lipid (0–20[Formula: see text]wt.%), solid lipid blends’ composition and dispersions’ solid content on nanoparticles size, zeta potentials, PI value, stability, matrix structure and UV absorption were investigated. The matrix structure of the lipids and the blends was investigated by using X-ray diffraction (XRD) techniques. The particle sizes were [Formula: see text]200[Formula: see text]nm and PI values are below 0.25 after production. The stability of lipid nanoparticles (LNs) was characterized by naked eye and dynamic light scattering (DLS) technique. The optimized lipid is the lanolin nanostructured lipid carrier with lecithin and APG 810 as co-emulsifiers.