SENSING DNA WITH ALTERNATING CURRENTS USING A NANOGAP SENSOR EMBEDDED IN A NANOCHANNEL DEVICE-Reference-Cited by-同舟云学术

SENSING DNA WITH ALTERNATING CURRENTS USING A NANOGAP SENSOR EMBEDDED IN A NANOCHANNEL DEVICE

Published:2013-03 Issue:01 Volume:03 Page:1340007
ISSN:1793-9844
Container-title:Nano LIFE
language:en
Short-container-title:Nano LIFE

Author:

DAVIS BRET H.¹,PAN JUNHAN¹,TUNG CHIH-KUAN²,AUSTIN ROBERT H.²,RIEHN ROBERT¹

Affiliation:

1. Department of Physics, North Carolina State University, Campus Box 8202, Raleigh, NC 27695, USA

2. Department of Physics, Princeton University, Jadwin Hall, Washington Road, Princeton, NJ 08544-0708, USA

Abstract

We report an integrated nanochannel/nanoelectrode sensor for the detection of DNA using alternating currents. We find that DNA can be detected using platinum as the metal for the detecting electrodes, with a signal to noise ratio exceeding 10. We argue that the signal is at least in part electrochemical in nature, thus holds the promise to yield a sequence-dependent signal. However, we also find that for large voltages, DNA attaches irreversibly to the driving electrodes.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1793984413400072

Reference29 articles.

1. Initial impact of the sequencing of the human genome

2. Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth

3. Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell

4. Recent advances in nanopore sequencing

5. Partial sequencing of a single DNA molecule with a scanning tunnelling microscope

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Electrode-embedded nanopores for label-free single-molecule sequencing by electric currents;RSC Adv.;2014

2. NANOTECHNOLOGY IN BIOLOGICAL DETECTION AND CHARACTERIZATION;Nano LIFE;2013-03