Synthesis and in vitro study of new highly boronated phthalocyanine

Author:

Shmal'ko Akim V.12,Efremenko Anastasija V.34,Ignatova Anastasija A.34,Sivaev Igor B.1,Feofanov Alexey V.34,Hamuryudan Esin5,Gül Ahmet5,Kovalenko Leonid V.2,Qi Shicheng6,Bregadze Vladimir I.1

Affiliation:

1. A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119991, Moscow, Russia

2. D. I. Mendeleev Russian Chemical Technological University, 9 Miusskaya Sq., 125047 Moscow, Russia

3. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklai, Str., 117997 Moscow, Russia

4. Biological Faculty, M.V. Lomonosov Moscow State University, 1 Vorob'evy Gory, 119992 Moscow, Russia

5. Department of Chemistry, Technical University of Istanbul, Maslak, TR34469 Istanbul, Turkey

6. College of Materials Science and Engineering, Beijing University of Chemical Technology, 100029 Beijing, China

Abstract

A new highly boronated Zn ( II )-phthalocyanine with eight cobalt bis(dicarbollide) units (144 boron atoms) was prepared and its intracellular accumulation and distribution in GL6 human glioblastoma cells were studied. It was found that the boronated phthalocyanine undergoes strong aggregation in intracellular environment.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Chemistry

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