Design and synthesis of protoporphyrin IX/vitaminB12molecular hybridsviaCuAACreaction

Abstract

The design and synthesis of new molecular hybrids composed of protoporphyrin IX (PPIX) and vitamin B12via copper catalyzed alkyne azide cycloaddition reaction is described. New, clickable aminoazide and aminoalkyne linkers were prepared and subsequently attached to PPIX (via vinyl group) and to vitamin B12giving desired building blocks. Preliminary results showed that respective water soluble hybrids were formed under CuAAC reaction. Gratifyingly, Cu incorporation into the PPIX core was avoided, which was important for further biological studies.