Heavy metal effects on physicochemical properties of non-aggregated azaphthalocyanine derivatives

Abstract

Two series of peripherally substituted azaphthalocyanines (AzaPcs) containing different transition metals ( Al(III), Zn(II), Ga(III), In(III) and Fe(II) ) were synthesized and studied for their photophysical properties. As confirmed by UV-vis and1H NMR analyses, the non-aggregation behavior was effectively induced by the applied bulky peripheral substituents which had no effect on the photophysical properties. Tuning the Q-band position was clearly achievable by using different central heavy metals which have considerable effects on the fluorescence quantum yield and singlet oxygen generation efficiency. This comparative study showed an interesting linear relationship between the former and atomic number of the central metal. The indium containing complexes exhibited the best result due to the heavy metal effect and therefore could be promoted as a potential photosensitizer in photodynamic therapy (PDT) application.