Syntheses, properties and cellular studies of metallo-isoporphyrins

Author:

Mwakwari Sandra C.1,Wang Haijun1,Jensen Timothy J.1,Vicente M. Graça H.1,Smith Kevin M.1

Affiliation:

1. Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA

Abstract

b-Bilene hydrochlorides are shown to be improved intermediates for the synthesis of metallo-isoporphyrins in enhanced yields (28% vs. 6%). Several new diamagnetic zinc(II) and a novel paramagnetic copper(II) isoporphyrin salts were also obtained using this approach. Metal-free isoporphyrins were also isolated. In vitro studies using human carcinoma HEp2 cells show that all metallo-isoporphyrins accumulate within cells and localize partially in the mitochondria. The zinc-isoporphyrins were found to be moderately phototoxic while the copper complex showed the lowest phototoxicity, maybe as a result of its paramagnetic nature.

Publisher

World Scientific Pub Co Pte Ltd

Subject

General Chemistry

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