Synthesis, RNA binding and nuclease activity of porphyrin-hydroxamic acid derivatives-Reference-Cited by-同舟云学术

Synthesis, RNA binding and nuclease activity of porphyrin-hydroxamic acid derivatives

Published:2012-09 Issue:09 Volume:16 Page:997-1005
ISSN:1088-4246
Container-title:Journal of Porphyrins and Phthalocyanines
language:en
Short-container-title:J. Porphyrins Phthalocyanines

Author:

Marketaki Maria¹,Touloupakis Eleftherios¹,Charalambidis Georgios¹,Chalbot Marie-Cécile¹,Ghanotakis Demetrios F.¹,Coutsolelos Athanassios G.¹

Affiliation:

1. Department of Chemistry, University of Crete, P.O. Box 2208, 71003 Voutes-Heraklion, Greece

Abstract

The interaction modes and nuclease activity against RNA of methylpyridiniumyl/phenyl-hydroxamic acid porphyrin adducts have been investigated. These compounds are derived from the tetracationic meso-tetrakis(N-methyl-4-pyridiniumyl)porphyrin (H2TMPyP-4) by replacing one or two pyridinium rings with a phenyl group. This group is bearing an aliphatic chain of three carbon atoms in the para position to a hydroxamic acid. A different interaction mode is observed depending on the number of charges and hydroxamic acid function. The nuclease activity of the porphyrin adducts against RNA has been demonstrated. Also the effect of the presence of various lanthanide ions on the porphyrin nuclease activity has been tested.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Chemistry

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1088424612501088

Reference38 articles.

1. Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA

2. Cationic Porphyrins Promote the Formation of i-Motif DNA and Bind Peripherally by a Nonintercalative Mechanism

3. Porphyrins in Photodynamic Therapy - A Search for Ideal Photosensitizers

4. The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n

5. Toxicity of Gold Nanoparticles Functionalized with Cationic and Anionic Side Chains

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