Tetra <i>vs.</i> octa - How it affects the photophysical, photochemical, physicochemical and biological properties of mercaptophenol-substituted Zn phthalocyanines-Reference-Cited by-同舟云学术

Tetra vs. octa - How it affects the photophysical, photochemical, physicochemical and biological properties of mercaptophenol-substituted Zn phthalocyanines

Published:2022-11 Issue:11 Volume:26 Page:701-707
ISSN:1088-4246
Container-title:Journal of Porphyrins and Phthalocyanines
language:en
Short-container-title:J. Porphyrins Phthalocyanines

Author:

Topkaya Derya¹,Aydın Derya²³,Aziza Haifa Ben⁴,Şahin Zeynel⁵,İşci Ümit²,Durand Denis⁶,Tazebay Uygar H.⁷⁸,Gary-Bobo Magali⁶,Dumoulin Fabienne⁴

Affiliation:

1. Dokuz Eylul University, Faculty of Sciences, Department of Chemistry, Tınaztepe Campus, Buca, Izmir, Türkiye

2. Gebze Technical University, Chemistry Department, 41400 Gebze, Kocaeli, Türkiye

3. Marmara University, Department of Chemistry, 34722 Kadikoy, Istanbul, Türkiye

4. Acıbadem Mehmet Ali Aydınlar University, Faculty of Engineering and Natural Sciences, Department of Biomedical Engineering, Ataşehir, Istanbul, Türkiye

5. Marmara University, Faculty of Technology, Department of Metallurgical & Materials Engineering, 34722 Istanbul, Türkiye

6. Institut de Biomolécules Max Mousseron, UMR 5247, Université de Montpellier, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 05, France

7. Gebze Technical University, Molecular Biology and Genetics Department, 41400 Gebze Kocaeli, Türkiye

8. Gebze Technical University, Centre Research Laboratory (GTU-MAR), Gebze 41400 Kocaeli, Türkiye

Abstract

Zn phthalocyanines tetra- and octa- substituted in peripheral positions by mercaptophenol moieties were prepared. Photophysical, photochemical, physicochemical and biological properties relevant from a photodynamic therapy point of view have been determined, showing that the tetra-substituted derivatives have better potential, confirmed by in vitro tests performed on MCF-7 cells that induced significant cell death without showing dark toxicity.

Funder

The Scientific and Technological Research Council of Türkiye

Publisher

World Scientific Pub Co Pte Ltd

Subject

General Chemistry

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1088424622500584

Reference19 articles.

1. Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

2. Overcoming the Achilles' heel of photodynamic therapy

3. Therapeutic applications of near‐infrared dyes

4. Modulation of the electronic and spectroscopic properties of Zn(ii) phthalocyanines by their substitution pattern

5. The synthesis of an octasubstituted monohydroxylated phthalocyanine designed to investigate the effect of the presence of active moieties