Potential of phthalocyanine on streptozotocin-induced diabetic rats: An initiative of dye in substitution of therapeutics

Abstract

Type 1 diabetes mellitus, is one of the severe chronic metabolic diseases with severe worldwide complications due to increased levels of glucose affecting many organ functionalities. Antioxidant properties reduce the free radicals and inhibit the oxidation that promotes cellular development in many conditions such as diabetes, Alzheimer’s disease and cardiovascular disorders. Phthalocyanine is a large blue colored aromatic compound with high potential of anti-oxidant ability owing to the presence of porphyrazine ring units. The present study has aimed at examining the potential effect of phthalocyanine on the streptozotocin-induced diabetic model over 28 days. For the study, the animals were assigned into 4 groups: control, diabetic, phthalocyanine (10 [Formula: see text]g/kg/day) treated diabetic group and phthalocyanine (20 [Formula: see text]g/kg/day) treated diabetic group. After the induction of diabetes using streptozotocin (53 mg/kg body weight), phthalocyanine (10 [Formula: see text]g/kg/day) and phthalocyanine (20 [Formula: see text]g/kg/day) were given daily for 28 days and the blood glucose level was checked on 7th, 14th, 21st and 28th day. A significant reduction in blood glucose within the period on the 28th day with increase in body weight was observed. Phthalocyanine also showed a decrease in the total protein content and blood urea nitrogen with improved oxidative stress parameters. The histopathological analyses displayed improvement in pancreatic structure with basal rounded nuclei and well-defined boundaries normal acini with a phthalocyanine dose (10 [Formula: see text]g/kg). It was concluded that phthalocyanine at the dose of 10 [Formula: see text]g/kg presented anti-diabetic and anti-hyperlipidemic actions with protective effect to the pancreatic [Formula: see text]-cell within 28 days.