Synthesis of alkylthio substituted pyridoporphyrazines and their photophysicochemical properties

Abstract

Phthalocyanine and their related compounds are utilized as various applications, such as photosensitizing agents for photodynamic therapy of cancer. In this study, zinc bis(thiodidecylbenzo)-bis(pyrido)porphyrazines, especially zinc bis(1,4-didecylthiobenzo)-bis(3,4-pyrido)porphyrazine and zinc bis(1,4-didecylthiobenzo)-bis(2,3-pyrido)porphyrazine were synthesized. Quaternation of the pyridine nitrogen in these provides an amphiphilic property. Photoexcited triplet lifetime of synthesized and quaternized zinc bis(1,4-didecylthiobenzo)-bis(3,4-pyrido)porphyrazine and zinc bis(1,4-didecylthiobenzo)-bis(2,3-pyrido)porphyrazine were reported using laser-flash photolysis and singlet oxygen quantum yields by the 1,3-diphenylisobenzofurne method.