New approach for the synthesis, docking of new porphyrins and their antitumor activity-Reference-Cited by-同舟云学术

New approach for the synthesis, docking of new porphyrins and their antitumor activity

Published:2019-03 Issue:03 Volume:23 Page:251-259
ISSN:1088-4246
Container-title:Journal of Porphyrins and Phthalocyanines
language:en
Short-container-title:J. Porphyrins Phthalocyanines

Author:

Tawfik Eman H.¹²,Fadda Ahmed A.²,Soliman Nanees N.²,Abou-Zeid Laila³,Negm Amr²

Affiliation:

1. Chemistry Department, Faculty of Science and Arts, Taibah University, Ulla, Kingdom of Saudi Arabia

2. Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt

3. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt

Abstract

A new methodology for the synthesis of a new series of mesotetrakis[aryl]-21H,23H-porphyrin derivatives 5a–5d, 6a–6c, 7 and 8 is presented. Structures of new compounds were established based on both elemental and spectral data. Cytotoxicity activity of the newly synthesized compounds was investigated against two human cell lines MCF-7 and HepG2. Molecular docking was performed to investigate the binding between the most active porphyrin derivatives and Bcl-2 molecular biomarkers in HepG2 cells.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Chemistry

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1088424619500093

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