Gadolinium complexes of chlorin derivatives applicable for MRI contrast agents and PDT

Abstract

One of the ultimate goals of contrast agent (CA) research in magnetic resonance imaging (MRI) is to identify tumor-seeking materials. Thus, cancer diagnosis by Photodynamic Therapy (PDT) using photosensitizer will be one of the best tools for cancer research. By linking paramagnetic gadolinium [ Gd(III) ] ion to tumor selective chlorin-based photosensitizers, the cancer cell can be easily detected with high sensitivity and cured by appropriate laser irradiation simultaneously. The synthesis of monomer and dimer chlorin derivatives, such as pyropheophorbide-a and purpurin systems, conjugated with Gd(III) diethylenetriaminepentaacetic acid (DTPA) by means of diethylene-triaminepentaacetic dianhydride (caDTPA) for the evaluation as CAs for MRI was described in the present study.