Functionalization of chlorins towards potential photosensitizers for photodynamic therapy-Reference-Cited by-同舟云学术

Functionalization of chlorins towards potential photosensitizers for photodynamic therapy

Published:2017-12 Issue:12 Volume:21 Page:908-917
ISSN:1088-4246
Container-title:Journal of Porphyrins and Phthalocyanines
language:en
Short-container-title:J. Porphyrins Phthalocyanines

Author:

Pont Francesc¹,Montforts Franz-Peter²

Affiliation:

1. CSL Behring GmbH, Emil-von-Behring Str.76, D-35041 Marburg, Germany

2. Institute of Organic Chemistry and Analytical Chemistry, FB 2, University of Bremen, Leobener Str. NW2/C, D-28359 Bremen, Germany

Abstract

Photophysical properties of chlorins predestine this type of hydroporphyrins for photodynamic therapy and other diagnostic/therapeutic applications. Artificial chlorins 3a and 4a derived from the red blood pigment heme form a platform for functionalizations with respect towards potentially biologically active photosensitizers and fluorescense markers. Chlorin estrogen derivatives 8a, 8b might be useful as sensitizers which bind selectively to (tumor) cell tissue containing estrogen receptors, [Formula: see text] breast cancer cells.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Chemistry

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1088424617500948

Reference5 articles.

1. An improved method for the preparation of formyldeuteroporphyrins - Synthesis of biologically relevant porphyrins

2. Differentiation of diastereomeric chlorin derivatives by fast atom bombardment mass spectrometry

3. Chemical Aspects of Photodynamic Therapy

4. The value of estrogen and progesterone receptors in the treatment of breast cancer

5. Synthesis of oxochlorins from the red blood pigment heme and their transformation into potentially biologically active chlorin derivatives

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4. Regioselective reduction of 5-aryl-10,15,20-tris(pyridyl) porphyrin to 5-aryl-10,15,20-tris(pyridyl)dihydroporphyrin (chlorin);Journal of Porphyrins and Phthalocyanines;2019-12

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