Synthesis of vitamin B12 derivatives with sodium hydroxymethanesulfinate-Reference-Cited by-同舟云学术

Synthesis of vitamin B12 derivatives with sodium hydroxymethanesulfinate

Published:2018-12 Issue:12 Volume:22 Page:1092-1098
ISSN:1088-4246
Container-title:Journal of Porphyrins and Phthalocyanines
language:en
Short-container-title:J. Porphyrins Phthalocyanines

Author:

Pugina Raida A.¹,Denisova Elena A.¹,Ivlev Pavel A.¹,Salnikov Denis S.¹,Makarov Sergei V.¹

Affiliation:

1. Department of Food Chemistry, State University of Chemistry and Technology, Sheremetevskiy str. 7, Ivanovo, 153000, Russia

Abstract

The reaction of cyanocobalamin (CNCbl) with sodium hydroxymethanesulfinate (HMS) was studied over a wide range of pH (4–11) under aerobic conditions. CNCbl is destroyed in the presence of HMS in aqueous solution to form uncolored substances. The accumulation of stable yellow corrinoids (SYCs) preceded these changes at pH [Formula: see text] 8. The major stable yellow corrinoid is (15R)-Co[Formula: see text], Coß — dicyano-13-dehydro-15-hydro-l5-hydroxycob(III)alamin. The yield of this SYC is 25%, and the stability of this compound decreases significantly with increasing concentrations of HMS, pH and temperature.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Chemistry

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1088424618501092

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