Porphyrins with directly meso-attached disaccharide moieties: Synthesis, self-assembly and cellular study

Author:

Malachowska Magdalena1,Sperduto Claudio1,Darmostuk Mariia2,Monti Donato3,Venanzi Mariano3,Mancini Giovana4,D'Acunto Cosimo Walter2,Králová Jarmila5,Ruml Tomáš2,Wimmer Zdenĕk16,Drašar Pavel B.1

Affiliation:

1. Dept Nat. Compds Chem., University of Chemical Technology, Prague, 16628 Prague 6, Czech Republic

2. Dept Biochem. Microbiol., University of Chemical Technology, Prague, 16628 Prague 6, Czech Republic

3. Dept Chem. Sci. Technol., University of Rome Tor Vergata, Via Della Ricerca Scientifica 1, 00133 Rome, Italy

4. IMR-CNR, c/o Dept Chem., University of Rome, La Sapienza, P.le A. Moro 5, 00185 Rome, Italy

5. Institute of Molecular Genetics AS CR, v.v.i., 142 20 Praha 4, Czech Republic

6. Isotope Laboratory, Institute of Experimental Botany AS CR, v.v.i., 142 20 Prague 4, Czech Republic

Abstract

A series of porphyrins with directly meso-attached “sucrose” moiety by the carbon C-6′ of its “fructose” end was synthesized, and their physico-chemical and aggregation properties studied by spectroscopic (fluorescence, circular dichroism, resonance light scattering) techniques. The effect of selected porphyrins on tumor cells was also evaluated.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Chemistry

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