Patient-Specific Echo-Based Left Ventricle Models for Active Contraction and Relaxation Using Different Zero-Load Diastole and Systole Geometries

Abstract

A new modeling approach using two different zero-load geometries (diastole and systole) was introduced to properly model active contraction and relaxation for more accurate stress/strain calculations. Ventricle diastole and systole material parameter values were also determined based on in vivo data. Echo-based computational two-layer left ventricle (LV) models using one zero-load geometry (1G) and two zero-load geometries (2G) were constructed. Material parameter values in Mooney–Rivlin models were also adjusted to match echo LV volume data. Effective Young’s moduli (YM) were calculated for ventricle materials for easy comparison. The 2G models may lead to more accurate ventricle stress/strain calculations and material parameter value estimations.