Development of La–graphene composite contrasting agents for photon-counting computed tomography

Author:

Suslova Evgeniya1,Shashurin Denis2,Kozlov Alexei1,Maximov Sergey1,Rozhkov Vladislav3,Sotenskii Rostislav3,Savilov Serguei1,Medvedev Oleg24,Chelkov Georgy3

Affiliation:

1. Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation

2. Faculty of Basic Medicine, Lomonosov Moscow State University, Moscow, Russian Federation

3. Joint Institute for Nuclear Research, Dubna, Russian Federation

4. Laboratory of Experimental Pharmacology, Institute of Experimental Cardiology, National Medical Research Center of Cardiology n.a. acad. E.I. Chazov of the Ministry of Health of the Russian Federation, Moscow, Russian Federation

Abstract

This work describes the synthesis, analysis, and testing of the novel type of La/graphene composites as potential contrasting agents (CAs) for photon-counting computed tomography (PCCT). The impregnation of oxidized graphene nanoflakes (GNFs) with Lanthanum nitrate solution resulted in uniform distribution of La-containing particles on the flake surface with particle size of about 2–3 nm. La was confirmed to be a suitable contrasting element for PCCT that could be visualized in reference phantom media and in the presence of other CAs. Minimum concentration of La in the composites determined by PCCT was in the range of 2.5–5 mg⋅ml[Formula: see text].

Publisher

World Scientific Pub Co Pte Ltd

Subject

General Materials Science

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