Detection of Chemotherapeutic Drug 6-Mercaptopurine Through Manipulating Localized Surface Plasmon Resonance Absorption of Silver Nanoplates

Abstract

A new colorimetric method for the detection of chemotherapeutic drug 6-mercaptopurine (6-MP) is developed based on controlling localized surface plasmon resonance (LSPR) of triangular silver nanoplates (AgNPs). The triangular AgNPs can be etched by trace amount of Cl− and transformed to a disc-like shape, accompanied by a blueshift of the corresponding LSPR absorption band. With the protective effect of 6-MP, the AgNPs are hardly or partly to be etched by Cl−, resulting in a reversed shift of LSPR. Based on a linear relationship between LSPR wavelength change and the concentration of 6-MP, a fast, visual and selective method for 6-MP assay is established. This method has been successfully applied to the detection of 6-MP in tablets.