SEMICONTINUOUS HETEROPHASE POLYMERIZATION AS A TOOL FOR PREPARING ULTRAFINE NANOPARTICLES OF IBUPROFEN-POLY(METHYL METHACRYLATE)-Reference-Cited by-同舟云学术

SEMICONTINUOUS HETEROPHASE POLYMERIZATION AS A TOOL FOR PREPARING ULTRAFINE NANOPARTICLES OF IBUPROFEN-POLY(METHYL METHACRYLATE)

Published:2014-08 Issue:06 Volume:09 Page:1450060
ISSN:1793-2920
Container-title:Nano
language:en
Short-container-title:NANO

Author:

SAADE HENED¹,GARZA JESUS CEPEDA¹,LOPEZ-QUINTANILLA MARIA LUISA¹,ENRIQUEZ-MEDRANO FRANCISCO¹,FERNANDEZ SALVADOR¹,LOPEZ RAUL GUILLERMO¹,RODRIGUEZ HAZYADEE²

Affiliation:

1. Departamento de Procesos de Polimerización, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna, 140, 25294, Saltillo, Coahuila, México

2. Departamento de Biotecnologia, Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Blvd. V. Carranza y José Cárdenas Valdés, S/N, 25280, Saltillo, Coahuila, México

Abstract

Ibuprofen-loaded poly(methyl methacrylate) nanoparticles with mean diameters smaller than 20 nm were prepared by a novel method. This consists in carrying out a semicontinuous heterophase polymerization, in which a solution of drug-monomer is added on a micellar solution at an appropriate dosing rate. Scanning transmission electron microscopy (STEM) measurements showed number-average diameters in the range 16–19 nm with 1.14–1.15 in polydispersity, determined as the ratio of weight-average to number-average diameter. Drug contents in nanoparticles close to 24% were determined by UV-Vis spectrophotometry, confirming the results obtained from a procedure that combines latex filtration and quasielastic light scattering (QLS) measurements. Differential scanning calorimetry (CDSC) determinations suggest that at the ibuprofen contents attained in this study, crystals and dispersed molecules of the drug coexist inside the nanoparticles. Based on the relative simplicity of the process it is expected that its use will be adopted to prepare ultrafine nanoparticles composed of different hydrophobic polymers and water insoluble drugs.

Publisher

World Scientific Pub Co Pte Lt

Subject

Condensed Matter Physics,General Materials Science

Link

https://www.worldscientific.com/doi/pdf/10.1142/S179329201450060X

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1. Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization;International Journal of Polymer Science;2018

2. Preparation of ultrafine poly(methyl methacrylate-co-methacrylic acid) biodegradable nanoparticles loaded with ibuprofen;Journal of Biomaterials Science, Polymer Edition;2016-05-12