SEMICONTINUOUS HETEROPHASE POLYMERIZATION AS A TOOL FOR PREPARING ULTRAFINE NANOPARTICLES OF IBUPROFEN-POLY(METHYL METHACRYLATE)

Author:

SAADE HENED1,GARZA JESUS CEPEDA1,LOPEZ-QUINTANILLA MARIA LUISA1,ENRIQUEZ-MEDRANO FRANCISCO1,FERNANDEZ SALVADOR1,LOPEZ RAUL GUILLERMO1,RODRIGUEZ HAZYADEE2

Affiliation:

1. Departamento de Procesos de Polimerización, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna, 140, 25294, Saltillo, Coahuila, México

2. Departamento de Biotecnologia, Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Blvd. V. Carranza y José Cárdenas Valdés, S/N, 25280, Saltillo, Coahuila, México

Abstract

Ibuprofen-loaded poly(methyl methacrylate) nanoparticles with mean diameters smaller than 20 nm were prepared by a novel method. This consists in carrying out a semicontinuous heterophase polymerization, in which a solution of drug-monomer is added on a micellar solution at an appropriate dosing rate. Scanning transmission electron microscopy (STEM) measurements showed number-average diameters in the range 16–19 nm with 1.14–1.15 in polydispersity, determined as the ratio of weight-average to number-average diameter. Drug contents in nanoparticles close to 24% were determined by UV-Vis spectrophotometry, confirming the results obtained from a procedure that combines latex filtration and quasielastic light scattering (QLS) measurements. Differential scanning calorimetry (CDSC) determinations suggest that at the ibuprofen contents attained in this study, crystals and dispersed molecules of the drug coexist inside the nanoparticles. Based on the relative simplicity of the process it is expected that its use will be adopted to prepare ultrafine nanoparticles composed of different hydrophobic polymers and water insoluble drugs.

Publisher

World Scientific Pub Co Pte Lt

Subject

Condensed Matter Physics,General Materials Science

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