Aβ Protein Detector Based on AAO Confined Self-Assembly System

Abstract

With the advent of the aging of the world’s population, the number of patients suffering from Alzheimer’s disease (AD) is increasing year by year, and how to diagnose early and treat AD has become a problem for the world. After decades of hard work, people have made a series of breakthroughs in the pathogenesis of AD. One of the most widely accepted is that there is a large amount of amyloid-[Formula: see text] protein deposition in the body of AD patients. This also provides us with a new idea for early diagnosis of AD. In this paper, a confined self-assembly system based on AAO/ZnS is constructed to specifically respond to amyloid-[Formula: see text] protein. The obtained samples were characterized by FESEM, XPS and UV–Vis. This system specifically recognizes A[Formula: see text] protein by modifying the tryptophan enantiomers. The experimental results show that the samples synthesized under the self-assembly system of modified D-Trp have higher response sensitivity to amyloid-[Formula: see text] protein. This provides a new idea for the self-assembly system based on the limited space of the nano-biomimetic channel in biological detection, and also shows great potential in improving the sensitivity of the biodetector.